Early clinical response to treatment predicts 5-year outcome in RA patients: follow-up results from the CAMERA study
| Autor: | P.M.J. Welsing, Marije F. Bakker, F.P.J.G. Lafeber, Evelien Ton, J. W. J. Bijlsma, Simone A Vreugdenhil, C van Booma-Frankfort, Suzanne P. Linn-Rasker, J. W. G. Jacobs |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Arthritis Blood Sedimentation General Biochemistry Genetics and Molecular Biology law.invention Arthritis Rheumatoid Pharmacotherapy Rheumatology Randomized controlled trial law Immunopathology Internal medicine medicine Humans Immunology and Allergy Aged business.industry Middle Aged medicine.disease Connective tissue disease Drug Therapy Computer-Assisted Surgery Radiography C-Reactive Protein Methotrexate Treatment Outcome Antirheumatic Agents Rheumatoid arthritis Disease Progression Female Epidemiologic Methods business Biomarkers medicine.drug |
| Zdroj: | Annals of the Rheumatic Diseases. 70:1099-1103 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | ObjectiveTo investigate the long-term effects of the tight control (TC) and conventional (CT) methotrexate-based strategies of the Computer Assisted Management in Early Rheumatoid Arthritis trial in early rheumatoid arthritis and evaluate the predictive value of an early response to treatment.MethodsClinical and radiographic 5-year outcome was compared between initial strategies. Patients were classified according to the EULAR response criteria. The prognostic value of early response to treatment in addition to established predictors was analysed by multiple linear regression analyses.Results5 years of data were available for 205 of 299 patients, with no indication for selective drop-out. At 5 years there was no longer any significant difference for clinical and radiographic outcomes between treatment strategies applied during the first 2 years. Good-responders had a mean disease activity score of 2.39 (1.2) and median yearly radiographic progression rate of 0.6 (0.0 to 2.2) at 5 years; significantly lower (both pConclusionsThe difference in disease activity between treatment strategies disappeared over the years. Good-response to treatment independently predicts significantly better 5-year clinical and radiographic outcome. The TC principle probably should be continued in the long-term. |
| Databáze: | OpenAIRE |
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