Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children
| Autor: | Selina Summermatter, Anastasios P Konstantinopoulos, Roberta Bonaguro, Yvonne M. Vissers, Sophie Nutten, Stavroula Giavi, Nikolaos G. Papadopoulos, Francesca Lazzarotto, Antonella Muraro, Antoine Wermeille, Remo Frei, R. Lauener, Annick Mercenier |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Eggs Immunology Administration Oral Placebo Immunoglobulin E Gastroenterology law.invention Immunophenotyping 03 medical and health sciences 0302 clinical medicine Immune system Randomized controlled trial law Food allergy Internal medicine Immunology and Allergy Medicine Humans Pyrophosphatases Egg Hypersensitivity Skin Tests biology business.industry Oral food challenge Maintenance dose Phosphoric Diester Hydrolases Tetraspanin 30 Infant Allergens medicine.disease Basophils Basophil activation Treatment Outcome 030228 respiratory system Desensitization Immunologic Child Preschool Immunoglobulin G biology.protein Female business 030215 immunology |
| Zdroj: | Giavi, S, Vissers, Y M, Muraro, A, Lauener, R, Konstantinopoulos, AP, Mercenier, A, Wermeille, A, Lazzarotto, F, Frei, R, Bonaguro, R, R. Bonaguro, S. Summermatter, S. Nutten, & Papadopoulos, N 2016, ' Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children ', Allergy . https://doi.org/10.1111/all.12905 |
| DOI: | 10.1111/all.12905 |
| Popis: | BackgroundA major drawback of oral immunotherapy for food allergy is the possibility of severe side-effects. We assessed both safety and efficacy of a low allergenic hydrolysed egg (HydE) preparation used in a double-blind placebo-controlled randomized study in egg allergic children.MethodsIn a pilot multicentre study, 29 egg allergic patients (aged 1–5.5 years) were administered daily for 6 months 9 g HydE or placebo in a blinded, randomized manner. Safety was verified by oral food challenge to assess tolerance towards HydE at the start and efficacy by an open oral food challenge (OFC, primary outcome) at the end. Additionally, changes in basophil activation and specific IgE and IgG4 were assessed.ResultsAll egg allergic patients randomized to HydE (n = 15) tolerated the full dose at day 1 and received the maintenance dose from the start at home. No statistically significant difference was observed on the final OFC (36% and 21% had a negative OFC in the treatment and placebo groups, respectively). Specific IgG4 levels increased, while both CD203c+ and CD63+ basophils decreased significantly more over time in the treatment than in the placebo group.ConclusionsHydE can be regarded as a safe, low allergenic product to use in children allergic to egg. Although not significant, HydE given for 6 months increased numerically the proportion of patients becoming tolerant to egg. HydE induced a modulation of the immune response towards better tolerance. A longer treatment period and/or a higher dose may improve the clinical outcome and should be evaluated. |
| Databáze: | OpenAIRE |
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