Are oxidative stress biomarkers and respiratory muscles strength associated with COPD-related sarcopenia in older adults?
| Autor: | Pedro Henrique Scheidt Figueiredo, Fabiana Angélica de Paula, Mario Bernardo-Filho, Henrique Silveira Costa, Joyce Noelly Vítor Santos, Liliana Pereira Lima, Guilherme Pinto da Silva, Antônio Lúcio Teixeira, Vanessa Kelly da Silva Lage, Hellen Cristina de Almeida, Vanessa Mendonça, Ana Cristina Rodrigues Lacerda, Redha Taiar, Jousielle Márcia dos Santos |
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| Rok vydání: | 2022 |
| Předmět: |
Male
Sarcopenia Aging medicine.medical_specialty medicine.disease_cause Biochemistry Superoxide dismutase Pulmonary Disease Chronic Obstructive Endocrinology Internal medicine Genetics Respiratory muscle TBARS Humans Medicine Muscle Strength Respiratory system Molecular Biology Aged COPD biology business.industry Cell Biology medicine.disease Ferric reducing ability of plasma Respiratory Muscles Oxidative Stress Cross-Sectional Studies biology.protein business Biomarkers Oxidative stress |
| Zdroj: | Experimental Gerontology. 157:111630 |
| ISSN: | 0531-5565 |
| DOI: | 10.1016/j.exger.2021.111630 |
| Popis: | Background Patients with chronic obstructive pulmonary disease (COPD) often present with sarcopenia, a condition marked by the loss in quality and quantity of muscle mass that can affect the strength of respiratory muscles. COPD and sarcopenia are also independently associated with oxidative stress. This study aimed to investigate whether oxidative stress biomarkers and respiratory muscle strength are associated with sarcopenia in COPD patients. Methods In a cross-sectional study, 86 elderly subjects, including subjects with and without COPD were assessed for body composition, maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) and oxidative stress parameters [substances reactive to thiobarbituric acid (TBARS), ferric reducing ability of plasma (FRAP), superoxide dismutase (SOD), and catalase (CAT)]. Results The sample was mainly composed by males (72.1%) and eutrophic subjects. COPD-related sarcopenia was evidenced in 51.1% (22/43) of subjects with COPD. The highest TBARS and CAT, and lower MIP and MEP were associated with a high probability of having COPD-related sarcopenia. In the multivariate analysis, TBARS (OR: 4.89, 95% CI 1.52 to 15.54, p = 0.006), CAT (OR: 1.22, 95% CI 1.03 to 1.45, p = 0.020) and MEP (OR: 0.97, 95% CI 0.95 to 0.99, p = 0.020) were independent determinants of COPD-related sarcopenia. Conclusion The increase in oxidative stress-related factors and the reduction of respiratory muscle strength are associated with COPD-related sarcopenia. |
| Databáze: | OpenAIRE |
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