Brain-derived Neurotropic factor (BDNF) mediates the protective effect of Cucurbita pepo L. on salivary glands of rats exposed to chronic stress evident by structural, biochemical and molecular study
| Autor: | Hanan S. Seleem, Emad A. Albadawi, Osama Ibrahim Ramadan, Nasra Naeim Ayuob, Zuhair M. Mohammedsaleh, Hadel M. Alghabban, Hailah M. Almohaimeed |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant medicine.medical_treatment Salivary Glands Cucurbita pepo chemistry.chemical_compound Cucurbita Corticosterone Internal medicine Fluoxetine medicine Animals Chronic stress General Dentistry Submandibular gland biology business.industry Depression Brain RK1-715 biology.organism_classification Parotid gland Rats medicine.anatomical_structure Endocrinology BDNF chemistry Apoptosis Dentistry Tumor necrosis factor alpha Original Article business Pumpkin |
| Zdroj: | Journal of Applied Oral Science v.29 2021 Journal of applied oral science Universidade de São Paulo (USP) instacron:USP Journal of Applied Oral Science Journal of Applied Oral Science, Vol 29 (2021) Journal of Applied Oral Science, Volume: 29, Article number: e20201080, Published: 04 OCT 2021 |
| Popis: | Acute and chronic stresses affect the salivary glands, representing the source of plasma BDNF during stressful conditions. Pumpkin is a medicinal plant with an evident antioxidant, anti-inflammatory and potential antidepressant effects. Objective To assess the structural and biochemical effects induced by exposure to chronic unpredictable mild stress (CUMS) on salivary glands of albino rats, and to evaluate the role of pumpkin extract (Pump) in ameliorating this effect. Methodology Four groups (n=10 each) of male albino rats were included in this study: the control, CUMS, Fluoxetine-treated and Pump-treated. The corticosterone, the pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and the oxidant/antioxidant profile were all assessed in the serum. The level of BDNF mRNA was measured in the salivary glands using qRT-PCR. Histopathological changes of the salivary glands were also assessed. Results The depressive-like status was confirmed behaviorally and biochemically. Exposure to CUMS significantly up-regulated (p |
| Databáze: | OpenAIRE |
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