Diphtheria outbreak in Maranhão, Brazil: microbiological, clinical and epidemiological aspects
| Autor: | Thereza Cristina Ferreira Camello, Raphael Hirata, R. Stavracakis-Peixoto, Priscila Soares Sabbadini, L. L. G. Borges, Cíntia Silva Santos, Verônica Viana Vieira, Fátima Napoleão, Gabriela Andrade Pereira, Louisy Sanches dos Santos, Ana Luíza Mattos-Guaraldi, Elisa Martins Ladeira, L. M. S. S. Cosme, Juliana Nunes Ramos, Lincoln de Oliveira Sant'Anna |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Epidemiology Microbial Sensitivity Tests Microbiology Disease Outbreaks Young Adult Cervical lymphadenopathy Drug Resistance Bacterial medicine Paralysis Humans Child Corynebacterium diphtheriae biology business.industry Diphtheria Outbreak medicine.disease biology.organism_classification Dermatology Original Papers Pharyngitis Electrophoresis Gel Pulsed-Field Penicillin Infectious Diseases Female medicine.symptom business Brazil medicine.drug |
| Zdroj: | Epidemiol Infect |
| ISSN: | 1469-4409 |
| Popis: | SUMMARYWe describe microbiological, clinical and epidemiological aspects of a diphtheria outbreak that occurred in Maranhão, Brazil. The majority of the 27 confirmed cases occurred in partially (n = 16) or completely (n = 10) immunized children (n = 26). Clinical signs and characteristic symptoms of diphtheria such as cervical lymphadenopathy and pseudomembrane formation were absent in 48% and 7% of the cases, respectively. Complications such as paralysis of lower limbs were observed. Three cases resulted in death, two of them in completely immunized children. Microbiological analysis identified the isolates asCorynebacterium diphtheriaebiovar intermedius with a predominant PFGE type. Most of them were toxigenic and some showed a decrease in penicillin G susceptibility. In conclusion, diphtheria remains endemic in Brazil. Health professionals need to be aware of the possibility of atypical cases ofC. diphtheriaeinfection, including pharyngitis without pseudomembrane formation. |
| Databáze: | OpenAIRE |
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