In vitroAntischistosomal and Cytotoxic Activities of Norneolignans fromStyrax pohliiA. DC
| Autor: | UO Gonçalves, Ana Helena Januário, Pollyanna Francielli de Oliveira, Eloá Soares, Márcio Luis Andrade e Silva, Vanderlei Rodrigues, Wilson Roberto Cunha, Denise Crispim Tavares, Camila Spereta Bertanha, Lizandra Guidi Magalhães, Patrícia Mendonça Pauletti |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
biology Traditional medicine Stereochemistry Styracaceae SCHISTOSOMA MANSONI (EFEITOS DE DROGAS) Homoegonol Egonol gentiobioside biology.organism_classification In vitro chemistry.chemical_compound Styrax pohlii Complementary and alternative medicine Glucoside chemistry Ic50 values Cytotoxic T cell |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1540-3580 1049-6475 |
| Popis: | The schistosomicidal and cytotoxic activities of norneolignans isolated from Styrax pohlii are used to relieve fever. The norneolignans homoegonol [2] and homoegonol glucoside [4] provided the best results against S. mansoni adult worms. At 200 μM, compounds 2 and 4 killed 25% and 50% of the parasites in 120 h, while egonol [1], homoegonol gentiobioside [3], and egonol gentiobioside [5] reduced their motor activity to 12.5%, 12.5%, and 37.5% in 120 h, respectively. With respect to the cytotoxic activity, the IC50 values were greater than 800 μM for 1, 5, and 3 and 192.5 and 253.1 μM for 2 and 4, respectively. |
| Databáze: | OpenAIRE |
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