The repetitive application of cold atmospheric plasma (CAP) improves microcirculation parameters in chronic wounds
| Autor: | Lysann Schulz, Jan-Oluf Jensen, Nico Matzkeit, Peter Mailaender, Markus Kleemann, Felix Stang, Robert Kraemer, Tobias Kisch, Sophie Schleusser, Henriette Deichmann |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Time Factors Plasma Gases Cutaneous microcirculation Biochemistry Microcirculation medicine Laser-Doppler Flowmetry Tissue oxygen Humans Prospective Studies Aged Skin Wound Healing business.industry Leg Ulcer Single application Cell Biology Blood flow Recovery of Function Laser Doppler velocimetry Middle Aged medicine.disease Diabetic foot Capillaries Treatment Outcome Oxygen Saturation Spectrophotometry Anesthesia Chronic Disease Female Cardiology and Cardiovascular Medicine Wound healing business |
| Zdroj: | Microvascular research. 138 |
| ISSN: | 1095-9319 |
| Popis: | Background Chronic wounds, such as venous leg ulcers, diabetic foot ulcers, and pressure ulcers, impose a significant burden on patients and health care systems worldwide. Cold atmospheric plasma (CAP) accelerates wound healing and decreases bacterial load in chronic wounds in both in vitro and in vivo experiments. For the first time, we examined the effects of a repetitive application of CAP on the microcirculation in chronic wounds. Hypothesis The repetitive application of cold atmospheric plasma application further improves microcirculation in chronic wounds. Methods Twenty patients with chronic wounds were treated repetitively with CAP. The repetitive application consisted of three CAP sessions, each lasting 90 s and separated by a 10-minute microcirculation measuring period. Microcirculation parameters were assessed with combined Laser-Doppler-Flowmetry and spectrophotometry in a tissue depth of 2 mm. Results Tissue oxygen saturation was significantly increased after the first CAP application. The effect amplitude and duration were further increased after the second and third CAP application with a maximum increase by 16,7% (percent change; p = 0,004 vs. baseline) after the third application. There was no significant increase in capillary blood flow until the third CAP application. After the third CAP application, an increase by 22,6% (p = 0,014) was observed. Postcapillary filling pressure was not significantly increased over the measuring period. The repetitive application of CAP further enhances the microcirculation in chronic wounds compared to a single application. Conclusion The repetitive application of CAP boosts and prolongs tissue oxygen saturation and capillary blood flow in chronic wounds compared to a single application. This insight could provide an impetus for new treatment protocols. |
| Databáze: | OpenAIRE |
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