Abnormal content of n−6 and n−3 long-chain unsaturated fatty acids in the phosphoglycerides and cholesterol esters of parahippocampal cortex from Alzheimer's disease patients and its relationship to acetyl CoA content
| Autor: | D.F. Horrobin, E. R. Skinner, F.M. Corrigan, M. B. Cooper, John A. O. Besson |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Chromatography Gas Phosphatidylserines Phosphatidylinositols Hippocampus Biochemistry chemistry.chemical_compound Acetyl Coenzyme A Alzheimer Disease Fatty Acids Omega-6 Phosphatidylcholine Fatty Acids Omega-3 Humans Phosphatidylinositol Aged Aged 80 and over chemistry.chemical_classification Phosphatidylethanolamine Chemistry Cholesterol Phosphatidylethanolamines Fatty Acids Acetyl-CoA Fatty acid Cell Biology Middle Aged Glycerophosphates Fatty Acids Unsaturated Phosphatidylcholines Female Arachidonic acid Cholesterol Esters Polyunsaturated fatty acid |
| Zdroj: | The International Journal of Biochemistry & Cell Biology. 30:197-207 |
| ISSN: | 1357-2725 |
| DOI: | 10.1016/s1357-2725(97)00125-8 |
| Popis: | The long-chain fatty acid composition of cholesterol esters, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylinositol (PI) from parahippocampal cortex of Alzheimer's disease (AD) patients and control subjects was examined. In general the PC fraction contained less polyunsaturated long-chain fatty acids than did PE, PS or PI. Of the n-6 polyunsaturated long-chain fatty acids, PI contained the greatest incorporation of these acids followed by PE. There were significant differences between controls and AD patients in total n-6 EFAs. Arachidonic acid (C20:4n-6) was the predominant fatty acid of this family found to be present. In AD, PE and PS showed a deficit of adrenic acid (C22:4n-6) content and PE also contained less arachidonic acid. In AD subjects, the cholesterol esters contained significantly less n-3 polyunsaturated fatty acids with, specifically, a reduction in alpha-linolenic acid. Acetyl CoA content of hippocampal cortex was greater in AD patients than in control subjects indicating either an increased extent of oxidative metabolism or a failure to utilise acetyl CoA for anabolic processes. Abnormal magnitude of oxidative processes could give rise to the biosynthesis of PE and PS species containing less n-6 polyunsaturated fatty acids than occurs in control subjects. |
| Databáze: | OpenAIRE |
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