O6-Alkylguanine-DNA-alkyltransferase activity in peripheral leukocytes, smoking and risk of lung cancer
| Autor: | Lorenzo Simonato, Vali Constantinescu, Päivi Pelkonen, Giovanni Schmid, Paolo Boffetta, Irene Brüske-Hohlfeld, Halina Batura-Gabryel, Fredrik Nyberg, Janet Hall, Anush Mukeria, Simone Benhamou |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Lung Neoplasms Passive smoking medicine.disease_cause Gastroenterology Tobacco smoke O(6)-Methylguanine-DNA Methyltransferase Internal medicine Leukocytes Odds Ratio medicine Humans Risk factor Lung cancer Aged business.industry Smoking Respiratory disease O-6-methylguanine-DNA methyltransferase Odds ratio Middle Aged medicine.disease Oncology Immunology Carcinogens Female business Alkyltransferase |
| Zdroj: | Cancer Letters. 180:33-39 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/s0304-3835(02)00014-9 |
| Popis: | The level of activity of O6-alkylguanine-DNA-alkyltransferase (AGT), a DNA repair enzyme, in blood lymphocytes may be a marker of susceptibility to lung cancer. We measured the AGT activity level, expressed as pmoles of repaired bases/mg protein, in leukocytes of 153 lung cancer cases (of whom 80 were never smokers) and 106 controls (76 never smokers) enrolled in eight centres from seven countries. Subjects were interviewed with respect to active smoking and exposure to environmental tobacco smoke (ETS). Among never smokers, the odds ratios (ORs) of lung cancer were 1.3 (95% confidence interval 0.5-3.9), 1.5 (0.6-4.1) and 1.4 (0.5-3.8) in quartiles of decreasing AGT activity level, as compared to the upper quartile (P value of test for linear trend 0.6). Corresponding ORs among smokers were 3.4 (0.9-13), 2.0 (0.5-8.3) and 0.4 (0.1-1.6) (P value of test for linear trend 0.4). No interaction was suggested between AGT activity level and either cumulative smoking or exposure to ETS. Reduced AGT activity was not clearly associated with increased lung cancer risk in either smokers or non-smokers. However, the small size of our study argues for a prudent interpretation of our results. |
| Databáze: | OpenAIRE |
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