2-Phenyl-4-(aminomethyl)imidazoles as potential antipsychotic agents. Synthesis and dopamine D2 receptor binding
| Autor: | Kristine Harris, T. V. Ramabhadran, John R. Peterson, Philip C. Ross, Kevin Huston, Andrew Thurkauf, Linda Cornfield, Karen Gerber, Robin Meade, Hutchison Alan J |
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| Rok vydání: | 1995 |
| Předmět: |
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Complementary Tertiary amine Chemistry Stereochemistry Receptors Dopamine D2 Antagonist Imidazoles Plasma protein binding CHO Cells Chemical synthesis Structure-Activity Relationship Dopamine receptor Dopamine receptor D2 Cricetinae Drug Discovery Chlorocebus aethiops Molecular Medicine Structure–activity relationship Animals Cloning Molecular Receptor Antipsychotic Agents Protein Binding |
| Zdroj: | Journal of medicinal chemistry. 38(12) |
| ISSN: | 0022-2623 |
| Popis: | A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D2 selective benzamide antipsychotics. The title compounds were synthesized and tested for blockade of [3H]YM-09151 binding in cloned African green monkey dopamine D2 receptor preparations. The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)-pyrroles. |
| Databáze: | OpenAIRE |
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