Bioactive Sulfated Sesterterpene Alkaloids and Sesterterpene Sulfates from the Marine Sponge Fasciospongia sp
| Autor: | Ghee Teng Tan, Tamara P. Kondratyuk, J. M. Pezzuto, Guangmin Yao, Leng Chee Chang |
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| Rok vydání: | 2009 |
| Předmět: |
Sesterterpenes
Stereochemistry Pharmaceutical Science Antineoplastic Agents Marine Biology Microbial Sensitivity Tests Sulfuric Acid Esters Pharmacognosy Streptomyces Analytical Chemistry Alkaloids Sulfation Drug Discovery Animals Humans Nuclear Magnetic Resonance Biomolecular Pharmacology Molecular Structure biology Bicyclic molecule Chemistry Alkaloid Organic Chemistry Biological activity biology.organism_classification Terpenoid Anti-Bacterial Agents Porifera Sponge Complementary and alternative medicine Molecular Medicine Female Drug Screening Assays Antitumor |
| Zdroj: | Journal of Natural Products. 72:319-323 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np8005343 |
| Popis: | Two new sulfated sesterterpene alkaloids, 19-oxofasciospongine A (3) and fasciospongine C (4), and a new sesterterpene sulfate, 25-hydroxyhalisulfate 9 (5), along with two known sesterterpene sulfates, halisulfates 7 (6) and 9 (7), were isolated from an organic extract of the marine sponge Fasciospongia sp. The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies as well as by HRESIMS analysis. Compounds 1-7 exhibited inhibitory activity against Streptomyces 85E in the hyphae-formation inhibition assay. Compounds 1, 2, and 4-7 were not cytotoxic when tested at 20 microg/mL with MCF-7, LNCaP, and LU cell lines. Only compound 3 demonstrated a moderate cytotoxic effect on the MCF-7 (IC(50) 13.4 microM), LNCaP (IC(50) 21.8 microM), and LU-1 cells (IC(50) 5.0 microM), respectively. |
| Databáze: | OpenAIRE |
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