Lack of correlation between the lifetimes of mRNA and the initial lengths of their poly a segments
| Autor: | E. V. Brykina, M. I. Lerman, T. V. Chernovskaya, O. V. Podobed |
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| Rok vydání: | 1974 |
| Předmět: |
Time Factors
Biology Mice Ribonucleases Drug Stability Polysome Genetics Animals Carbon Radioisotopes RNA Messenger Pancreas Molecular Biology Orotic Acid Messenger RNA Base Sequence Adenine General Medicine Ribonucleotides Molecular biology Adenosine Monophosphate Molecular Weight Kinetics Liver Isotope Labeling Polyribosomes Dactinomycin Electrophoresis Polyacrylamide Gel |
| Zdroj: | Molecular Biology Reports. 1:417-422 |
| ISSN: | 1573-4978 0301-4851 |
| DOI: | 10.1007/bf00385675 |
| Popis: | In mouse liver polyribosomes two poly A-containing messenger RNA species have been found: a short-lived one with a lifetime of 1 to 1.5 hr in the free polyribosomes and a more stable with a lifetime of 5 to 6 hr. When both species of the steady-state labeled mRNAs were examined for poly A size distribution, they showed sets of similar size (170A–70A), indicating no direct dependence upon the initial length of poly A and the lifetimes of the corresponding mRNAs. Poly A in both species of mRNA is actually shortened during the ‘cold’ and ‘actinomycin d chase’. From these results it was concluded that the rate of shortening of poly A, rather than its initial length, could control the mRNA stability. |
| Databáze: | OpenAIRE |
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