Heterogeneity of DNA Ploidy Pattern in Carcinoma of the Gallbladder: Primary and Metastatic Sites
| Autor: | Yoshiyuki Esaki, Wataru Kimura, Noriaki Futakawa, Hidehiko Ando, Tetsuichiro Muto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1997 |
| Předmět: |
Male
Cancer Research Pathology medicine.medical_specialty Aneuploidy Biology Article Metastasis medicine Carcinoma Humans Neoplasm Invasiveness Neoplasm Metastasis Peritoneal Neoplasms Aged Neoplasm Staging Aged 80 and over Ploidies Gallbladder Liver Neoplasms DNA Neoplasm medicine.disease Nuclear DNA DNA ploidy pattern Survival Rate medicine.anatomical_structure Oncology Lymphatic Metastasis Monoclonal Cancer cell Cancer research Stemline Female Gallbladder Neoplasms Lymph Nodes Ploidy Heterogeneity Gallbladder carcinoma |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 1876-4673 0910-5050 |
| Popis: | There are few detailed reports on the heterogeneity of the nuclear DNA ploidy pattern in carcinoma of the gallbladder. We studied twelve autopsied cases who died of extended gallbladder carcinoma. Multiple samples were taken from the primary site (Pri), from direct invasion of the liver (Hinf), from hematogenous metastasis to the liver (H), from lymphatic metastasis (LN) and from peritoneal dissemination (P). The DNA ploidy pattern was investigated by image cytometry. Heterogeneity of the DNA ploidy pattern in Pri, Hinf, H, LN and P was found in 7/11, 2/10, 5/10, 2/6 and 3/6 cases, respectively. Aneuploidy was more frequently found in Hinf than at the Pri. The DNA index of Hinf was significantly higher than that of Pri. Several stemlines, with different quantities of DNA, were found in Pri. Most of these stemlines were also observed in other sites. These facts may suggest that polyclonal cancer cells rather than one cancer cell or monoclonal cancer cells of a Pri metastasize or infiltrate, and that various polyclonal cancer cells proliferate to different degrees under different circumstances. |
| Databáze: | OpenAIRE |
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