Diagnosis options in patients suffering from COVID‐19‐like symptoms

Autor: Sébastien Lhomme, Samia Collot, Jacques Izopet, Chloé Dimeglio, Nicolas Sans, Marie Faruch, Karine Sauné, Florence Abravanel
Přispěvatelé: Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Virologie [Toulouse], CHU Toulouse [Toulouse]
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Chest ct
Computed tomography
Antibodies
Viral
Serology
03 medical and health sciences
0302 clinical medicine
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Virology
MESH: COVID-19 / diagnosis
medicine
Humans
In patient
False Positive Reactions
030212 general & internal medicine
Medical diagnosis
Lung
MESH: Antibodies
Viral / blood
MESH: Humans
medicine.diagnostic_test
MESH: False Positive Reactions
business.industry
SARS-CoV-2
MESH: COVID-19 / diagnostic imaging
fungi
COVID-19
MESH: SARS-CoV-2 / immunology
MESH: Lung / diagnostic imaging
3. Good health
body regions
MESH: COVID-19 Nucleic Acid Testing
medicine.anatomical_structure
Infectious Diseases
COVID-19 Nucleic Acid Testing
030211 gastroenterology & hepatology
Radiology
business
Tomography
X-Ray Computed
MESH: Tomography
X-Ray Computed
Zdroj: Journal of Medical Virology
Journal of Medical Virology, Wiley-Blackwell, 2021, 93 (7), pp.4076-4077. ⟨10.1002/jmv.26724⟩
ISSN: 0146-6615
1096-9071
DOI: 10.1002/jmv.26724⟩
Popis: The role and performance of chest CT in the diagnosis of the coronavirus disease 2019 pandemic remains under active investigation. A recent case report in this journal found that a COVID-19 diagnosis has been made from the serological results despite first CT scan and RT-PCR negative results. We have included 311 consecutive patients with COVID-19-like symptoms who underwent a RT-PCR test on nasopharyngeal swab samples and a chest CT scan. Patients with a positive chest scan and a negative RT-PCR were screened for serum total anti-SARS-CoV-2 antibodies 2 months after the onset of symptoms using the Wantai test in order to arbitrate between RT-PCR and CT scans discordant results. Most of the RT-PCR and chest CT results agreed but the serological tests indicate that most CT positive/NAT negative patients are not infected by SARS-CoV-2 and alternative diagnoses should be seriously considered. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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