Bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against gram-negative bacilli
| Autor: | Theodore Sacks, John Jacobs, J. Michel |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Pharmacology
Antibiotics Antineoplastic Time Factors Bacteria biology Klebsiella pneumoniae Antineoplastic Antibiotic Microbial Sensitivity Tests biology.organism_classification Antimicrobial medicine.disease_cause Anti-Bacterial Agents Microbiology Proteus Infectious Diseases medicine Drug Interactions Pharmacology (medical) Antibacterial activity Antagonism Escherichia coli Research Article |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 16:761-766 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.16.6.761 |
| Popis: | Six antineoplastic antibiotics showed little antibacterial activity against 28 strains of four species of gram-negative enteric bacteria. By using the cellophane transfer technique, combinations of these agents with 16 antibacterial drugs usually showed indifference. However, combinations of mitomycin C, especially with the aminoglycosides, were synergistic on strains of Escherichia coli, Proteus, and Klebsiella pneumoniae. Bleomycin, on the other hand, often showed antagonism on strains of E. coli and K. pneumoniae with the beta-lactams, aminoglycosides, and other antibacterial agents. Checkerboard titrations and kinetic killing curves confirmed these findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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