Reference Values of Reticulocyte Hemoglobin Content and Their Relation With Other Indicators of Iron Status in Healthy Children
| Autor: | Antonio Bonillo-Perales, María A Vázquez-López, Francisco Lendinez-Molinos, Rafael Galera-Martínez, Encarnación López-Ruzafa, Manuel Martín-González, Juan Poveda-González |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Reticulocytes Iron Physiology 030204 cardiovascular system & hematology 03 medical and health sciences Hemoglobins 0302 clinical medicine Reticulocyte Reference Values Receptors Transferrin medicine Humans Child Erythropoietin biology medicine.diagnostic_test business.industry Transferrin saturation Complete blood count Infant Hematology Iron deficiency medicine.disease Ferritin medicine.anatomical_structure Cross-Sectional Studies Oncology 030220 oncology & carcinogenesis Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Erythropoiesis Female Hemoglobin business medicine.drug |
| Zdroj: | Journal of pediatric hematology/oncology. 38(7) |
| ISSN: | 1536-3678 |
| Popis: | Reticulocyte hemoglobin content (CHr) is considered an indicator of functional iron deficiency, but is understudied in children. The goals of this study are to determine the reference intervals for CHr in healthy children, and their relation with iron parameters, erythropoiesis, and individual conditions. A total of 902 children without iron deficiency, aged 1 to 11 years were analyzed in a cross-sectional study. Besides a physical examination of the subjects and a questionnaire completed by their parents, the complete blood count, serum transferrin receptor, ferritin, transferrin saturation, erythrocyte protoporphyrin, serum erythropoietin, C-reactive protein, and CHr levels were measured. Changes in CHr, iron status, and erythropoiesis at different age intervals were analyzed and linear multiple regression was used to identify the factors that determine CHr variability. Mean value obtained for CHr was 30.9±1.8 pg (P2.5-P97.5: 26.9 to 34.3 pg), but the influence of age on CHr (the values increased with age) and on the iron parameters justified the establishment of different reference ranges. In addition to age, nutritional status, hematologic measurements, reticulocytes, transferrin saturation, and erythrocyte protoporphyrin accounted for 39% of CHr variability. |
| Databáze: | OpenAIRE |
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