Solid Lipid Nanoparticles Produced via a Coacervation Method as Promising Carriers for Controlled Release of Quercetin

Autor: Gemma Leone, Gabriella Tamasi, Agnese Magnani, Marco Consumi, Luigi Talarico
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Time Factors
antioxidant
Static Electricity
Spectrometry
Mass
Secondary Ion
Pharmaceutical Science
02 engineering and technology
030226 pharmacology & pharmacy
Article
Antioxidants
Analytical Chemistry
03 medical and health sciences
chemistry.chemical_compound
QD241-441
0302 clinical medicine
Dynamic light scattering
Spectroscopy
Fourier Transform Infrared
Drug Discovery
Solid lipid nanoparticle
Zeta potential
Particle Size
Physical and Theoretical Chemistry
Drug Carriers
Coacervate
Organic Chemistry
021001 nanoscience & nanotechnology
Lipids
Controlled release
Dynamic Light Scattering
solid lipid nanoparticles
chemistry
Chemical engineering
FTIR
Chemistry (miscellaneous)
Delayed-Action Preparations
Drug delivery
drug delivery
Nanoparticles
Molecular Medicine
Quercetin
Stearic acid
0210 nano-technology
coacervation
ToF-SIMS
controlled release
FTIR
Quercetin
ToF-SIMS
antioxidant
coacervation
controlled release
drug delivery
solid lipid nanoparticles
Zdroj: Molecules
Volume 26
Issue 9
Molecules, Vol 26, Iss 2694, p 2694 (2021)
ISSN: 1420-3049
DOI: 10.3390/molecules26092694
Popis: Quercetin is a poorly water-soluble flavonoid with many benefits to human health. Besides the natural food resources that may provide Quercetin, the interest in delivery systems that could enhance its bioavailability in the human body has seen growth in recent years. Promising delivery system candidates are represented by Solid Lipid Nanoparticles (SLNs) which are composed of well-tolerated compounds and provide a relatively high encapsulation efficiency and suitable controlled release. In this study, Quercetin-loaded and negatively charged Solid Lipid Nanoparticles were synthesized based on a coacervation method, using stearic acid as a core lipid and Arabic Gum as a stabilizer. Samples were qualitatively characterized by Dynamic light scattering (DLS), Zeta Potential, Surface infrared spectroscopy (FTIR-ATR), and Time of flight secondary ion mass spectrometry (ToF-SIMS). Encapsulation efficiency, drug release, and antioxidant effect against ABTS•+ were evaluated in vitro by UV–VIS spectrophotometry.
Databáze: OpenAIRE
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