Gold Nanoparticles as a Versatile Platform for Optimizing Physicochemical Parameters for Targeted Drug Delivery
| Autor: | Suzie H. Pun, Horst A. von Recum, Jamie M. Bergen, Archna P. Massey, Thomas T. Goodman |
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| Rok vydání: | 2006 |
| Předmět: |
Biodistribution
Magnetic Resonance Spectroscopy Materials science Polymers and Plastics Surface Properties Nanoparticle Bioengineering Nanotechnology Polyethylene Glycols Biomaterials Mice Drug Delivery Systems Lectins Materials Chemistry Animals Surface charge chemistry.chemical_classification Galactose Polymer Nanostructures Mice Inbred C57BL Targeted drug delivery chemistry Colloidal gold Drug delivery Hepatocytes Female Gold Particle size Biotechnology |
| Zdroj: | Macromolecular Bioscience. 6:506-516 |
| ISSN: | 1616-5195 1616-5187 |
| DOI: | 10.1002/mabi.200600075 |
| Popis: | The development of targeted vehicles for systemic drug delivery relies on optimizing both the cell-targeting ligand and the physicochemical characteristics of the nanoparticle carrier. A versatile platform based on modification of gold nanoparticles with thiolated polymers is presented in which design parameters can be varied independently and systematically. Nanoparticle formulations of varying particle size, surface charge, surface hydrophilicity, and galactose ligand density were prepared by conjugation of PEG-thiol and galactose-PEG-thiol to gold colloids. This platform was applied to screen for nanoparticle formulations that demonstrate hepatocyte-targeted delivery in vivo. Nanoparticle size and the presence of galactose ligands were found to significantly impact the targeting efficiency. Thus, this platform can be readily applied to determine design parameters for targeted drug delivery systems.Modified gold nanoparticles are a suitable model for nanoparticle-based gene carriers. |
| Databáze: | OpenAIRE |
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