Interleukin 8 correlates with intestinal involvement in surgically treated infants with necrotizing enterocolitis
| Autor: | Andreas Gleiss, Stephan C. Kettner, Thomas M. Benkoe, Carlos A. Reck, Winfried Rebhandl, Ernst Horcher, Andreas Repa |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pathology medicine.medical_treatment Bacteremia Gestational Age Infant Premature Diseases Sensitivity and Specificity Severity of Illness Index Gastroenterology Leukocyte Count Enterocolitis Necrotizing Predictive Value of Tests White blood cell Laparotomy Internal medicine Preoperative Care medicine Humans Pneumatosis Cystoides Intestinalis Enterocolitis business.industry Interleukin-8 Infant Newborn Infant Interleukin General Medicine Odds ratio medicine.disease digestive system diseases Intestines C-Reactive Protein medicine.anatomical_structure ROC Curve Predictive value of tests Pediatrics Perinatology and Child Health Necrotizing enterocolitis Biomarker (medicine) Female Surgery medicine.symptom business Biomarkers Infant Premature |
| Zdroj: | Journal of Pediatric Surgery. 47:1548-1554 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2011.11.049 |
| Popis: | The aim of this study was to test the predictive value of interleukin (IL) 8 in the assessment of intestinal involvement in necrotizing enterocolitis (NEC).Forty infants with surgically treated NEC were classified into 3 groups based on intestinal involvement during laparotomy: focal (n = 11), multifocal (n = 16), and panintestinal (n = 13). Preoperatively obtained serum levels of IL-8, C-reactive protein, white blood cell count, and platelet count were correlated with intestinal involvement using logistic regression models.Interleukin 8 correlated significantly with intestinal involvement in infants with surgically treated NEC (odds ratio, 1.74; confidence interval, 1.27-2.39; P.001). An exploratory IL-8 cutoff value of 449 pg/mL provided a specificity of 81.8% and sensitivity of 82.8% to discriminate focal from multifocal and panintestinal disease. An IL-8 cutoff value of 1388 pg/mL provided a specificity of 77.8% and a sensitivity of 76.9% to discriminate panintestinal disease from focal and multifocal disease.To our knowledge, this is the first study to demonstrate a significant correlation of IL-8 with intestinal involvement in advanced NEC in a large patient population. Our results indicate that IL-8 may be a promising biomarker for assessing intestinal involvement in infants with advanced NEC. |
| Databáze: | OpenAIRE |
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