Sickle cell chronic lung disease among young adult Nigerians
| Autor: | A E Fawibe, Alakija K Salami, P. O. Oluboyo |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Spirometry
Adult Lung Diseases Male medicine.medical_specialty Adolescent Sickle cell anaemia chronic lung disease adult Nigerians Black People Nigeria Disease Anemia Sickle Cell Chest pain Asymptomatic Young Adult Risk Factors Internal medicine medicine Prevalence Humans Young adult medicine.diagnostic_test business.industry Case-control study General Medicine medicine.disease Acute chest syndrome Surgery Respiratory Function Tests Case-Control Studies Chronic Disease Female medicine.symptom business Respiratory Insufficiency |
| Zdroj: | West African Journal of Medicine; Vol 29, No 1 (2010) |
| ISSN: | 0189-160X |
| Popis: | Sickle cell chronic lung disease (SCLD) is often underappreciated by health care providers because its exact prevalence and methods of diagnosis have not been well studied.To describe the pattern of SCLD among young adult Nigerians with sickle cell anaemia (SCA).its exact prevalence and methods of diagnosis have not been well studied.To describe the pattern of SCLD among young adult Nigerians with sickle cell anaemia (SCA).Ninety (43 males and 47 females) patients with SCA who were selected by balloting and 90 (54 males and 36 females) healthy subjects with normal adult haemoglobin were studied. Their ventilatory function test (spirometry and peak expiratory flow rates), radiological and electocardiographic parameters were obtained and analyzed for SCLD.Seventeen (18.9%) of the patients had SCLD. Majority (94.1%) of them were in stage1 disease, 5.9% in stage two, and none in the more advanced stages3 and 4. The number of patients with SCLD increased with increasing age. SCLD was associated with more than five previous hospital admissions: 82.4%, (OR of 10.02; CI:4.51 to 22.22) and presence of symptoms suggesting previous acute chest syndrome: dyspnoea in 58.8% (OR of 33.33, CI 7.39 to 150.30); chest pain in 94.1%, (OR of 81.33, CI 9.83 to 672.85); and cough in 47.1%, (OR of 64.00, CI 7.15 to 572.60).SCLD may not be a rare event in Nigeria. Therefore efforts should be made to diagnose it in the early asymptomatic stage so as to offer effective intervention therapy to halt progression to the more disabling advanced stages. |
| Databáze: | OpenAIRE |
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