Cognitive slowing associated with elevated serum anticholinergic activity in older individuals is decreased by caffeine use
| Autor: | Edythe M. Halligan, Robert D. Nebes, Patricia R. Houck, Judith Saxton, Bruce G. Pollock |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Neuropsychological Tests Article Cholinergic Antagonists Elevated serum chemistry.chemical_compound Cognition Internal medicine Caffeine medicine Anticholinergic Reaction Time Humans Psychiatry Paraxanthine Aged Working memory Cognitive test Psychiatry and Mental health Memory Short-Term chemistry Observational study Female Geriatrics and Gerontology Psychology Cognition Disorders Drug Antagonism |
| Popis: | Objectives This study examined whether some of the age-associated decrements in basic cognitive resources (information-processing speed and working memory) result from anticholinergic medication use (as measured by serum anticholinergic activity [SAA]) and whether such decrements are lessened by caffeine. Design Cross-sectional observational study. Setting University medical center. Participants One hundred fifty-two normal-elderly community volunteers. Measurements Two tests each of information-processing speed and of working memory were administered, and blood samples were drawn before and after cognitive testing to determine serum levels of anticholinergic activity and of paraxanthine—a caffeine metabolite. Results Elevated SAA was associated with a significant but modest slowing in information-processing time but only in those individuals who had low levels of serum paraxanthine. SAA did not correlate with performance on tests of working memory. Conclusions These results suggest that anticholinergic medications are a relatively minor contributor to the decrements in basic processing resources commonly found in studies of normal aging. |
| Databáze: | OpenAIRE |
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