EFFECT OF MUSCARINE ON RELEASE OF CATECHOLAMINES FROM THE PERFUSED ADRENAL GLAND OF THE CAT
| Autor: | J. C. Prat, S.M. Kirpekar, M. T. Schiavone |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Nicotine
medicine.medical_specialty In Vitro Techniques chemistry.chemical_compound Catecholamines Muscarine Internal medicine Adrenal Glands Muscarinic acetylcholine receptor medicine Animals Pharmacology Veratridine Adrenal gland Perfusion medicine.anatomical_structure Endocrinology Nicotinic agonist chemistry Cats Potassium Catecholamine Calcium Research Article medicine.drug |
| Zdroj: | British Journal of Pharmacology. 77:455-460 |
| ISSN: | 0007-1188 |
| DOI: | 10.1111/j.1476-5381.1982.tb09318.x |
| Popis: | 1 The secretory effect of muscarine was studied in the perfused adrenal gland of the cat. During perfusion of the adrenal gland with Krebs-bicarbonate solution containing muscarine 480 microM, the rate of catecholamine (CA) secretion was 2.02 +/- 0.43 micrograms/2 min in the first 2 min; thereafter, CA output declined only moderately, to reach about 70% of the initial value after 10 min. Secretory responses to brief infusions of muscarine remained reproducible for at least the first 3 infusions. 2 When the adrenal gland was perfused with muscarine (480 microM), infusions of high K+, nicotine, or veratridine produced their usual responses. A 100 fold lower dose of muscarine also failed to modify these responses. 3 During perfusion with high K+, muscarine evoked a secretory response that was only slightly smaller than the response to muscarine alone. 4 It is concluded that muscarine and nicotine activate CA secretion in the cat adrenal gland by independent mechanisms and that the muscarinic response, unlike the nicotinic response, is not readily desensitized. |
| Databáze: | OpenAIRE |
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