Antimicrobial Polymers of Linear and Bottlebrush Architecture: Probing the Membrane Interaction and Physicochemical Properties

Autor: Alain Murhimalika Bapolisi, Patrycja Kielb, Marek Bekir, Anne‐Catherine Lehnen, Christin Radon, Sophie Laroque, Petra Wendler, Henrike M. Müller‐Werkmeister, Matthias Hartlieb
Přispěvatelé: Publica
Rok vydání: 2022
Předmět:
Zdroj: Macromolecular Rapid Communications. 43:2200288
ISSN: 1521-3927
1022-1336
Popis: Polymeric antimicrobial peptide mimics are a promising alternative for the future management of the daunting problems associated with antimicrobial resistance. However, the development of successful antimicrobial polymers (APs) requires careful control of factors such as amphiphilic balance, molecular weight, dispersity, sequence, and architecture. While most of the earlier developed APs focused on random linear copolymers, the development of APs with advanced architectures proved to be more potent in the mimicry of antimicrobial peptides. We recently developed multivalent bottlebrush APs with improved antibacterial and hemocompatibility profiles, outperforming their linear counterparts. Understanding the rationale behind the outstanding biological activity of these newly developed antimicrobials is vital to further improving their performance. This work investigates the physicochemical properties governing the differences in activity between linear and bottlebrush architectures using diverse spectroscopic and microscopic techniques. Linear copolymers are more solvated, thermo-responsive and possess facial amphiphilicity resulting in random aggregations when interacting with liposomes mimicking E. coli-membranes. The bottlebrush copolymers adopt a more stable secondary conformation in aqueous solution in comparison to linear copolymers, conferring rapid and more specific binding mechanism to membranes. The advantageous physicochemical properties of the bottlebrush topology seem to be a determinant factor in the activity of these promising APs.
Databáze: OpenAIRE
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