Correlation between copper speciation and transport pathway in Caco‐2 cells

Autor: Min Wu, Cong Wang, Leqin Ke, Dewen Chen, Yumei Qin, Jianzhong Han
Rok vydání: 2022
Předmět:
Zdroj: Journal of the Science of Food and Agriculture. 103:1895-1900
ISSN: 1097-0010
0022-5142
DOI: 10.1002/jsfa.12292
Popis: Previous studies have demonstrated that, in contrast to the properties of food-derived copper, water-derived copper exerts neurotoxic effects and exhibits different speciation during digestion. The cellular uptake efficiencies of different speciation of copper are distinct. However, it is unclear whether these different speciation share the same transport pathway in intestinal epithelial cells. In the present study, the intracellular accumulation of copper derived from copper ion and copper complex solutions was investigated in Caco-2 cells.The cellular accumulation of copper derived from copper ions was higher than that of copper derived from the copper complex. Treatment with carboplatin and AgThese results indicate that the intracellular accumulation of copper derived from copper ion and copper complex is mediated by distinct copper transport pathways. Copper speciation may be an important factor that affects copper absorption and toxicity. © 2022 Society of Chemical Industry.
Databáze: OpenAIRE
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