Nanomaterial-Based Modulation of Tumor Microenvironments for Enhancing Chemo/Immunotherapy
| Autor: | Juhan Suh, Yu-Kyoung Oh, Quoc-Viet Le |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_treatment
Cancer therapy Pharmaceutical Science Anticancer chemotherapy 030226 pharmacology & pharmacy Extracellular matrix 03 medical and health sciences 0302 clinical medicine Neoplasms Tumor Microenvironment Medicine Animals Humans Chemo immunotherapy Tumor microenvironment Analgesics Drug Carriers business.industry Immunotherapy Nanostructures Immune toxicity 030220 oncology & carcinogenesis Cancer research Nanomedicine business |
| Zdroj: | The AAPS journal. 21(4) |
| ISSN: | 1550-7416 |
| Popis: | The tumor microenvironment (TME) has drawn considerable research attention as an alternative target for nanomedicine-based cancer therapy. Various nanomaterials that carry active substances have been designed to alter the features or composition of the TME and thereby improve the delivery and efficacy of anticancer chemotherapeutics. These alterations include disruption of the extracellular matrix and tumor vascular systems to promote perfusion or modulate hypoxia. Nanomaterials have also been used to modulate the immunological microenvironment of tumors. In this context, nanomaterials have been shown to alter populations of cancer-associated fibroblasts, tumor-associated macrophages, regulatory T cells, and myeloid-derived suppressor cells. Despite considerable progress, nanomaterial-based TME modulation must overcome several limitations before this strategy can be translated to clinical trials, including issues related to limited tumor tissue penetration, tumor heterogeneity, and immune toxicity. In this review, we summarize recent progress and challenges of nanomaterials used to modulate the TME to enhance the efficacy of anticancer chemotherapy and immunotherapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink