Elevated Serum Growth Hormone in Protein-Deprived Rats, and Decreased Liver RNA after Hypophysectomy
| Autor: | Kjartan Seyer-Hansen, Claus Rerup, Unne Stenram, Per-Inge Christensson |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Male
medicine.medical_specialty Orotic acid Hypophysectomy Swine medicine.medical_treatment Biochemistry chemistry.chemical_compound Protein Deficiency Internal medicine Casein medicine Animals Hydrocortisone Triiodothyronine Chemistry Liver cell Body Weight Caseins RNA Blood Proteins DNA Rats Endocrinology Liver Growth Hormone Pituitary Gland Dietary Proteins medicine.drug |
| Zdroj: | Hoppe-Seyler´s Zeitschrift für physiologische Chemie. 356:591-598 |
| ISSN: | 0018-4888 |
| Popis: | Serum growth hormone was significantly higher in rats fed on a non-protein than on a 25% casein diet. In both dietary groups, hypophysectomy provoked a decrease in the RNA/DNA ratio of the liver, and, especially in the protein-deprived rats, a decrease in the RNA synthesis per liver cell, measured as the product of the RNA/DNA ratio, and the ratio of specific RNA activity to specific nucleotide activity, two hours after administration of [3H]orotic acid. In the protein-deprived rats, full reconstitution of these figures was obtained with a combination of growth hormone, hydrocortisone and triiodothyronine, but not quite with growth hormone alone. The possible role of growth hormone in protein deprivation is discussed. |
| Databáze: | OpenAIRE |
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