A novel herpes simplex virus gene (UL49A) encodes a putative membrane protein with counterparts in other herpesviruses
| Autor: | Barbara C. Barnett, Andrew J. Davison, Duncan J. McGeoch, Aidan Dolan, Elizabeth A.R. Telford |
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| Rok vydání: | 1992 |
| Předmět: |
Signal peptide
Genetics Base Sequence Genes Viral viruses Molecular Sequence Data virus diseases Biology medicine.disease_cause Virology Virus Viral Matrix Proteins Open Reading Frames Open reading frame Herpes simplex virus Membrane protein Sequence Homology Nucleic Acid Putative gene medicine Simplexvirus Coding region Amino Acid Sequence Gene Herpesviridae |
| Zdroj: | Journal of General Virology. 73:2167-2171 |
| ISSN: | 1465-2099 0022-1317 |
| DOI: | 10.1099/0022-1317-73-8-2167 |
| Popis: | Comparative analysis of DNA sequences located between the coding regions of genes UL49 and UL50 of herpes simplex virus types 1 and 2 (HSV-1 and -2) has revealed a small open reading frame (ORF) of 91 and 87 codons respectively with the characteristics of a genuine protein-coding region. The predicted protein products are clearly related and exhibit features of membrane-inserted proteins, with potential N-proximal signal peptides and C-proximal membrane anchor regions. Counterparts are present in the other sequenced alphaherpesviruses, namely varicella-zoster virus (a previously undescribed gene, 9A) and equine herpesvirus type 1 (gene 10), in the betaherpesvirus human cytomegalovirus (gene UL73) and in the gammaherpesvirus Epstein-Barr virus (gene BLRF1). Therefore, we consider that this ORF represents an additional HSV gene (UL49A) with counterparts in all sequenced alpha-, beta- and gammaherpesviruses. |
| Databáze: | OpenAIRE |
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