Autor: |
Shuyu, Liu, Shinsuke, Mohri, Yuki, Manabe, Akika, Ejima, Kenji, Sato, Tatsuya, Sugawara |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Journal of Photochemistry and Photobiology B: Biology. 237:112601 |
ISSN: |
1011-1344 |
Popis: |
Photoaging is characterized by skin dysfunction and wrinkle formation predominantly caused by chronic exposure to ultraviolet (UV) irradiation. Collagen peptides are well-recognized as nutritional supplements for enhancing skin health. Gly-Pro, a dipeptide found in collagen as a major repetitive sequence, is considered a prospect collagen peptide derivative that displays anti-photoaging potential. Herein, we evaluated the photoprotective effects of Gly-Pro in normal human dermal fibroblasts (NHDFs). Pretreatment by Gly-Pro at a concentration of 0.1 μM inhibited UVA-driven generation of reactive oxygen species (ROS) in NHDFs and attenuated UVA-induced changes in mRNA expression and activation of proteins of the MAPK-NF-κB signaling pathway. Meanwhile, Pro-Gly and cyclo(-Gly-Pro), two dipeptides that are structurally similar to Gly-Pro, depicted less anti-photoaging effects against UVA irradiation. Collectively, our data suggests that Gly-Pro has potential as a novel ingredient in nutricosmetic products for skincare and anti-photoaging. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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