Cytotoxic diterpenoid quinonemethides from the roots of Pygmacopremna herbacea
| Autor: | T. Prabhakar Rao, Sistla Ramakrishna, M. Marthanda Murthy, Kovela Satish, M. Subrahamanyam, Krishnan Ravikumar, V. Lakshma Nayak, G. Srihari, M.V.P.S. Vishnuvardhan, B. Sridhar |
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| Rok vydání: | 2011 |
| Předmět: |
Stereochemistry
Clinical Biochemistry Molecular Conformation Ethyl acetate Pharmaceutical Science Crystallography X-Ray Plant Roots Biochemistry HeLa chemistry.chemical_compound Cell Line Tumor Verbenaceae Drug Discovery Humans Cytotoxic T cell Indolequinones Cytotoxicity Molecular Biology biology Organic Chemistry Data interpretation biology.organism_classification Antineoplastic Agents Phytogenic Terpenoid Hexane chemistry Molecular Medicine Diterpenes Drug Screening Assays Antitumor |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 21:4581-4584 |
| ISSN: | 0960-894X |
| Popis: | Two new diterpenoid quinonemethides (1 and 2) along with two known compounds (3 and 4) were isolated from the hexane and ethyl acetate extracts of root nodules of Pygmacopremna herbacea. The structures of the new compounds were established by spectroscopic data interpretation. Single crystal X-ray diffraction analysis confirmed the structure of 1. The cytotoxic activities of these compounds were evaluated against A 549, HEPG2, MCF-7, PC-3 and HELA cancer cell lines. Compounds 4, 2 and 1 were shown very good cytotoxic activity. |
| Databáze: | OpenAIRE |
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