Growth-inhibition and change in morphology and motility of sclc cell-lines by hepatocyte growth-factor scatter factor

Autor:	Toshikazu Nakamura, K Rygaard, B Klausen, M Spangthomsen
Rok vydání:	2011
Předmět:	Cancer Research Oncogene Cell Motility Cell cycle Biology respiratory tract diseases Cell biology chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry Cell culture medicine Hepatocyte growth factor Growth inhibition Receptor medicine.drug
Zdroj:	International journal of oncology. 2(6)
ISSN:	1019-6439
Popis:	Expression of the c-met proto-oncogene is common iii small cell lung cancer (SCLC) cell lines. The product of this proto-oncogene is the receptor for hepatocyte growth factor (HGF), also known as scatter factor (SF) and hepatopoietin A. We examined the effect of HGF/SF on 8 SCLC cell lines of which six expressed c-Met and 2 control cell lines did not. The effect was monitored by growth curves, in vitro migration in Boyden chambers. and by examination of morphology. Three cell lines responded in one or more of the following ways: Growth inhibition, morphological alterations. and increased migration in Boyden chambers. We conclude that functional c-Met receptors are frequently expressed in SCLC and may contribute to the behaviour of this tumour type.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258e45def1eb916302ab986ac4aeabd2 https://pubmed.ncbi.nlm.nih.gov/21573658 Zobrazit plný text záznamu