Sodium-lithium countertransport in children with nephrotic syndrome
| Autor: | Tivadar Tulassay, Peter Sallay, Andrea Luczay, Antal Szabó, Gusztáv Stubnya, M. Dobos, Barna Vásárhelyi, G Reusz |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Nephrotic Syndrome Lithium (medication) Sodium Natriuresis Renal function chemistry.chemical_element Antiporters Excretion Reference Values Edema Internal medicine Humans Medicine Child business.industry Glomerulonephritis medicine.disease Endocrinology chemistry Nephrology Child Preschool Pediatrics Perinatology and Child Health Female medicine.symptom business Nephrotic syndrome medicine.drug |
| Zdroj: | Pediatric Nephrology. 13:510-513 |
| ISSN: | 1432-198X 0931-041X |
| Popis: | The mechanisms of sodium retention in edema-forming minimal change nephrotic syndrome (MCNS) have not been completely evaluated. The aim of this study was to characterize the transmembrane sodium transport in nephrotic syndrome by measuring the erythrocyte sodium-lithium countertransport (SLC) in vitro. Eighteen children with MCNS were studied in the edema-forming state, and subsequently at the beginning of remission. Nephrotic children with edema retained sodium (10+/-12 micromol/day) and had a higher SLC [426+/-118 vs. 281+/-60 micromol/l red blood cells (RBC) per hour, P=0.003). The intracellular sodium concentration of nephrotics was 6.1+/-2.1 mmol/l RBC, which did not differ from that of controls (6.42+/-2.24, n=13). In remission sodium balance became negative (-30+/-21 mmol/day), and the SLC decreased but still differed significantly from control values (P=0.009). The intracellular sodium content decreased to 4.4+/-0.9 mmol/l RBC (P=0.002). There was a negative correlation between erythrocyte SLC and plasma albumin concentration (r=0.48, P=0.003), and urinary sodium excretion rate (r=0.66, P=0.001). In conclusion, erythrocyte SLC is high in the edema-forming state of childhood nephrotic syndrome and decreases with the onset of remission. A role for the SLC in the altered sodium homeostasis of nephrotic syndrome is suggested. |
| Databáze: | OpenAIRE |
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