Abnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson’s syndrome
| Autor: | Luca Roncati, Lorenzo Corsi, Giuseppe Barbolini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Pediatrics Thrombotic microangiopathy Coronavirus disease 2019 (COVID-19) 030204 cardiovascular system & hematology Catastrophic antiphospholipid syndrome Asherson’s syndrome Abnormal immunothrombosis Antiphospholipid syndrome (Hughes syndrome) Lupus anticoagulant (LAC) Megakaryocytes Article 03 medical and health sciences 0302 clinical medicine Fatal Outcome Internal medicine medicine Genetic predisposition Humans 030212 general & internal medicine Disseminated intravascular coagulation Lupus anticoagulant Hematology Thromboinflammation business.industry Mortality rate COVID-19 medicine.disease Antiphospholipid Syndrome Lupus Coagulation Inhibitor Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Thrombosis and Thrombolysis |
| Popis: | Background Coronavirus disease 2019 (COVID-19) is a complex disease with many clinicopathological aspects, including abnormal immunothrombosis, and the full comprehension of its pathogenetic mechanisms is urgently required. Methods/Results By means of a multidisciplinary approach, we here report a catastrophic COVID-19 in a 44-year-old Philippine male patient, discovered lupus anticoagulant (LAC)-positive shortly before death, occurred 8 days after hospitalization in a clinical scenario refractory to standard high acuity care recalling Asherson’s syndrome (catastrophic antiphospholipid syndrome). Conclusion A parallelism between this severe form of COVID-19 and Asherson’s syndrome can be so drawn. Both the diseases in fact exhibit hypercytokinemia, thrombotic microangiopathy, disseminated intravascular coagulation and multiple organ failure, they show a relationship with viral infections, and they are burdened by a high mortality rate. A genetic predisposition to develop these two overlapping conditions may be supposed. |
| Databáze: | OpenAIRE |
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