The Oriented Development of Antituberculotics (Part II): Halogenated 3-(4-Alkylphenyl)-1,3-benzoxazine-2,4-(3H)-diones

Autor:	Josef Matyk, Jarmila Kaustová, Petra Husáková, Hana Divišová, Karel Waisser, Jiri Kunes, Vera Klimesova, Karel Palát
Rok vydání:	2007
Předmět:	Magnetic Resonance Spectroscopy biology Chemistry Antitubercular Agents Pharmaceutical Science Dioxoles Microbial Sensitivity Tests Salicylanilides biology.organism_classification Combinatorial chemistry Mycobacterium Structure-Activity Relationship Phenols Active compound Oxazines Drug Discovery
Zdroj:	Archiv der Pharmazie. 340:264-267
ISSN:	1521-4184 0365-6233
Popis:	Based on our previous studies, 21 new halogenated 3-(4-alkylphenyl)-1,3-benzoxazine-2,4-(3H)-diones were synthesized by the reaction of salicylanilides and methyl-chloroformate. All compounds were screened in vitro against three different strains of mycobacterium, and Free-Wilson method was used to establish structure-activity relationships. 6-Bromo-3-(4-butylphenyl)-1,3-benzoxazine-2,4-(3H)-dione 3b proved to be the most active compound of the series.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25883302d5df1ca1584201b56fdc0e1b https://doi.org/10.1002/ardp.200600002 Zobrazit plný text záznamu Plný text