Flow cytometric analysis of uterine sarcomas
| Autor: | Stendahl Ulf, Tribukait Bernard, Kjellberg Lennart, Boquist Lennart |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Pathology Multivariate analysis Age at menopause Uterus Flow cytometry S Phase medicine Humans Stage (cooking) Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test business.industry Obstetrics and Gynecology Cell Differentiation Sarcoma DNA Neoplasm Middle Aged medicine.disease Aneuploidy Flow Cytometry Prognosis Survival Rate medicine.anatomical_structure Oncology In utero Multivariate Analysis Uterine Neoplasms Histopathology Female business |
| Zdroj: | Gynecologic oncology. 55(3 Pt 1) |
| ISSN: | 0090-8258 |
| Popis: | Eighty-four women with sarcoma uteri were evaluated on the basis of histopathological examination findings. In 45 of the 84 cases, a flow cytometric measure of DNA content and S-phase fraction was performed. Thirty-seven cases of the 45 were available for estimation of S-phase fraction. The histopathologic examination of paraffin-embedded tumor tissue revealed 44% leiomyosarcomas, 25% homologous mixed mullerian tumors, 17% endometrial stromacell sarcomas, 7% heterologous mixed mullerian tumors, 1% rhabdomyosarcomas, and 6% unclassified sarcomas. Eighty-six percent of the tumors were aneuploid, 14% were peridiploid, and the 5-year survivals were 20 and 60%, respectively. Clinical stage and lymphocytic reaction were found to be good prognostic parameters. Multivariate analysis of 5-year survival adjusted for age at menopause, clinical stage, mitotic frequency, lymphocytic response, and S-phase fraction did not give any further significant prognostic factors. |
| Databáze: | OpenAIRE |
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