Pathological characteristics and prognostic indicators of different histopathological types of urinary bladder cancer following radical cystectomy in a large single-center Egyptian cohort
| Autor: | Ahmed Abdelhalim, Ahmed A. Shokeir, Mohamed A. Ghoneim, Ahmed Mosbah, Yair Lotan, Ramy F. Youssef, Hassan Abol-Enein, Rahul Dutta, Simone L Vernez, Jeremy W. Martin |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Lymphovascular invasion Urology medicine.medical_treatment 030232 urology & nephrology Adenocarcinoma Cystectomy Single Center Gastroenterology Disease-Free Survival Cohort Studies Schistosomiasis haematobia Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Neoplasm Invasiveness Stage (cooking) Lymph node Pathological Aged Neoplasm Staging Retrospective Studies Aged 80 and over Carcinoma Transitional Cell Bladder cancer business.industry Middle Aged Prognosis medicine.disease medicine.anatomical_structure Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Carcinoma Squamous Cell Egypt Female Lymph Nodes Neoplasm Grading business |
| Zdroj: | World Journal of Urology. 36:1835-1843 |
| ISSN: | 1433-8726 0724-4983 |
| Popis: | To evaluate differences in pathological features and prognostics across four bladder cancer histopathological types: urothelial carcinoma (UC), urothelial carcinoma with variant histology (UCV), squamous cell carcinoma (SCC) and adenocarcinoma (ADC), utilizing a large cohort of radical cystectomy (RC) patients. A retrospective analysis of patients who underwent RC at a single institution in Egypt between 1997 and 2004 was performed. Kaplan–Meier and multivariable analyses were performed to evaluate the prognostic significance of pathological features including tumor stage, grade, lymphovascular invasion (LVI), and lymph node (LN) involvement in the different subtypes on disease-free survival (DFS). 1238 patients (975 male, 263 female) were included, of whom 577 (47%) had UC, 174 (14%) UCV, 398 (32%) SCC, and 89 (7%) ADC. Median age was 54 (20–87) years and median follow-up was 40 months (0–110). There were significant differences in stage, grade, LVI, LN involvement, and presence of schistosomiasis across the subtypes (all p |
| Databáze: | OpenAIRE |
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