Investigation of the chemical composition and biological activity of edible grapevine (Vitis vinifera L.) leaf varieties
| Autor: | Marija Lesjak, Dejan Orčić, Sanja Berežni, Dragana Četojević-Simin, Diandra Pintać, Neda Mimica-Dukić |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Antioxidant
medicine.medical_treatment Drug Evaluation Preclinical Raw material Biology 01 natural sciences Antioxidants Analytical Chemistry 0404 agricultural biotechnology Nutraceutical Tandem Mass Spectrometry Cell Line Tumor Lc ms ms medicine Humans Vitis Vitis vinifera Chemical composition Flavonoids 010401 analytical chemistry Ms analysis Biological activity 04 agricultural and veterinary sciences General Medicine Antineoplastic Agents Phytogenic 040401 food science 0104 chemical sciences Plant Leaves Horticulture Neuroprotective Agents Lipid Peroxidation Serbia Chromatography Liquid Food Science |
| Zdroj: | Food Chemistry. 286:686-695 |
| ISSN: | 0308-8146 |
| DOI: | 10.1016/j.foodchem.2019.02.049 |
| Popis: | © 2019 Elsevier Ltd Chemical composition and bioactivity of eight edible Vitis vinifera L. leaf varieties originating from Fruška Gora, Serbia, including two autochthonous varieties, were evaluated. The LC-MS/MS analysis confirmed the presence of 28 natural products in leaf samples, among which most abundant were glycosylated flavonoids, ellagic and chlorogenic acids. The highest amounts of most of the tested compounds were detected in leaves of autochthonous variety Sila. Bioactivity was assessed by a set of in vitro antioxidant, neuroprotective and cytotoxic assays. Leaves of all examined varieties exhibited average bioactivity, with leaves of autochthonous variety Župljanka standing out as the most promising sample. To conclude, investigated grapevine leaves proved to be a rich source of nutraceuticals, primarily antioxidants, and their further employment as medicinal food in human diet and beneficial raw material for food, pharmaceutical and cosmetic industries should be supported. |
| Databáze: | OpenAIRE |
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