Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics
| Autor: | Sergios-Orestis Kolokotronis, Timothy Nessel, Elizabeth Henaff, David Gandara, Noah Alexander, Angela Jones, Sean Ennis, Nell Kirchberger, Shanin Chowdhury, Jeanne Garbarino, Isaac Garcia, Darryl Reeves, Michael Walsh, Tanzina Nawrin, Cem Meydan, Jorge Gandara, Amber Simmons, Sofia Ahsanuddin, Shawn Levy, Elizabeth Alter, Jane M. Carlton, Collin Boyer, Nick Bernstein, Ebrahim Afshinnekoo, Joel T. Dudley, Tiago R. Magalhaes, Braden E. Boone, Bharathi Sundaresh, Eric E. Schadt, Sean Dhanraj, Robert J. Prill, Scott Tighe, Gregory D. O'Mullan, Paul Zumbo, Ellen Jorgensen, Elizabeth Pereira, Katie Schneider Paolantonio, Priyanka Vijay, Dyala Jaroudi, Julia M. Maritz, Anya Dunaif, Christopher E. Mason, Theodore R. Muth, Yogesh Saletore, Eoghan O'Halloran, Sagar Chhangawala |
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| Jazyk: | angličtina |
| Předmět: |
Histology
Geospatial analysis media_common.quotation_subject Biology computer.software_genre Article Pathology and Forensic Medicine World Wide Web 03 medical and health sciences 0302 clinical medicine 11. Sustainability Microbiome City scale Built environment Organism 030304 developmental biology media_common 0303 health sciences Disease surveillance Ecology Resolution (electron density) Cell Biology 13. Climate action Metagenomics 030220 oncology & carcinogenesis Cartography computer Diversity (politics) |
| Zdroj: | Cell systems |
| ISSN: | 2405-4712 |
| DOI: | 10.1016/j.cels.2015.07.006 |
| Popis: | SUMMARY The panoply of microorganisms and other species present in our environment influence human health and disease, especially in cities, but have not been profiled with metagenomics at a city-wide scale. We sequenced DNA from surfaces across the entire New York City (NYC) subway system, the Gowanus Canal, and public parks. Nearly half of the DNA (48%) does not match any known organism; identified organisms spanned 1,688 bacterial, viral, archaeal, and eukaryotic taxa, which were enriched for harmless genera associated with skin (e.g., Acinetobacter). Predicted ancestry of human DNA left on subway surfaces can recapitulate U.S. Census demographic data, and bacterial signatures can reveal a station’s history, such as marine-associated bacteria in a hurricane-flooded station. Some evidence of pathogens was found (Bacillus anthracis), but a lack of reported cases in NYC suggests that the pathogens represent a normal, urban microbiome. This baseline metagenomic map of NYC could help long-term disease surveillance, bioterrorism threat mitigation, and health management in the built environment of cities. Graphical Abstract |
| Databáze: | OpenAIRE |
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