Purslane (Portulaca oleracea) Seed Consumption And Aerobic Training Improves Biomarkers Associated with Atherosclerosis in Women with Type 2 Diabetes (T2D)
| Autor: | Ashril Yusof, Sekaran Muniandy, Khadijeh Gholami, Firouzeh Dehghan, Parvin Farzanegi, Mitra Abolmaesoomi, Mohammad Ali Azarbayjani, Rahman Soori, Sara Heidarzadeh |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Type 2 diabetes Portulaca 030204 cardiovascular system & hematology Placebo Gas Chromatography-Mass Spectrometry Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Risk Factors Internal medicine Botany medicine Aerobic exercise Humans Extracellular Signal-Regulated MAP Kinases Exercise Triglycerides Aged Creatinine Multidisciplinary business.industry Cholesterol Plant Extracts Middle Aged medicine.disease Atherosclerosis Lipoproteins LDL 030104 developmental biology Endocrinology chemistry Diabetes Mellitus Type 2 Seeds Urea Fatty Acids Unsaturated Uric acid Female business Lipoproteins HDL Biomarkers Lipoprotein Phytotherapy |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers to purslane seed consumption and aerobic training in women with T2D. 196 women with T2D were assigned into; (1) placebo (PL), (2) aerobic training+placebo (AT + PL), 3) purslane seeds (PS), aerobic training+purslane seeds (AT + PS). The training program and purslane seeds consumption (2.5 g lunch and 5 g dinner) were carried out for 16 weeks. The components of purslane seed were identified and quantified by GC–MS. Blood samples were withdrawn via venipuncture to examine blood glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, triglycerides (TG), creatinine, urea, uric acid, NF-κB, GLP1, GLP1R, TIMP-1, MMP2, MMP9, CRP, CST3, and CTSS expressions. Blood glucose, LDL, cholesterol, TG, creatinine, urea, and uric acid levels in the (P), (AT), and (AT + PS) groups were significantly decreased compared to the pre-experimental levels or the placebo group, while HDL, significantly increased. Furthermore, the protein and mRNA levels of NF-κB, TIMP-1, MMP2 &9, CRP, CST3, and CTSS in the (P), (AT), (AT + PS) significantly decreased compared to pre-experimental or the placebo group, while level of GLP1 and GLP1-R increased drastically. Findings suggest that purslane seed consumption alongside exercising could improve atherosclerosis plaque biomarkers through synergistically mechanisms in T2D. |
| Databáze: | OpenAIRE |
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