Germline TCR-A restriction of immunoglobulin E responses to allergen
| Autor: | J. A. Faux, William O.C.M. Cookson, Carsten Schou, M. F. Moffatt |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Receptors Antigen T-Cell alpha-beta Immunology Population Biology Immunoglobulin E medicine.disease_cause Germline Allergen Antigen Genetics medicine Animals Humans Allele education House dust mite HLA-D Antigens Mites education.field_of_study T-cell receptor Allergens biology.organism_classification Antibody Formation biology.protein Female |
| Zdroj: | Immunogenetics. 46:226-230 |
| ISSN: | 1432-1211 0093-7711 |
| DOI: | 10.1007/s002510050266 |
| Popis: | Immunoglobulin E responses to known environmental antigens (allergens) may serve as a general model to investigate germline genetic restriction of the immune response. We have previously shown genetic linkage between IgE responses to major allergens and the T-cell receptor (TCR) A/D locus, but not to TCR-B, implying that elements in TCR A/D restrict the ability to react to specific antigens. We now show, in two sets of subjects from the same population, a strong allelic association between a VA8.1 polymorphism (VA8.1(*)2) and reactivity to Der p II, a major antigenic component of the house dust mite Dermatophagoides pteronyssinus. Association was also seen between Der p II IgE titres and HLA-DRB1(*)1501 alleles. Reactivity to Der p II was confined to subjects who were positive for VA8.1(*)2 and HLA-DRB1(*)1501, demonstrating germline HLA-DR and TCR-A interaction in restricting the response to exogenous antigen. |
| Databáze: | OpenAIRE |
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