Alterations in skin microvascular function in patients with rheumatoid arthritis and ankylosing spondylitis
| Autor: | Anna Skalska, Mariusz Korkosz, Tomasz Grodzicki, Barbara Gryglewska, Ewa Klimek, Joanna Sulicka, Beata Kwaśny-Krochin |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Inflammatory arthritis Arthritis 030204 cardiovascular system & hematology Fibrinogen Systemic inflammation Gastroenterology Microcirculation Arthritis Rheumatoid Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Physiology (medical) Internal medicine Laser-Doppler Flowmetry medicine Humans Spondylitis Ankylosing Interleukin 6 Skin 030203 arthritis & rheumatology Ankylosing spondylitis biology business.industry Hematology Middle Aged medicine.disease C-Reactive Protein Rheumatoid arthritis biology.protein Female medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Clinical Hemorheology and Microcirculation. 65:77-91 |
| ISSN: | 1875-8622 1386-0291 |
| DOI: | 10.3233/ch-15112 |
| Popis: | OBJECTIVE To evaluate the relationship between systemic inflammation and skin microcirculation in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS). METHODS We assessed skin microcirculation flux (laser Doppler flowmetry), classical cardiovascular risk factors, inflammatory markers and disease activity (Disease Activity Score 28, Bath Ankylosing Spondylitis Disease Activity Index) in 75 patients with arthritis with a median disease duration of 4 years, and in 26 healthy subjects. RESULTS In patients with arthritis inflammatory markers (C-reactive protein, interleukin 6, fibrinogen) were increased, peak flux velocity after the occlusion at the temperature of 36.6°C and maximal heat flux velocity after the heating were significantly lower. These findings were accompanied by the slower increase in the flux rate during local heating. There were positive correlations between inflammatory markers and microcirculation parameters in patients with RA and AS, but only for RA patients between peak flux velocity and disease activity. There were no significant intergroup differences when the classical cardiovascular risk factors were compared except for the lower HDL cholesterol in arthritis patients. CONCLUSIONS Patients with chronic systemic inflammatory arthritis presented altered microvascular function and reduced vasodilator capacity of the forearm skin microcirculation. |
| Databáze: | OpenAIRE |
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