Erythrocyte cAMP in Determining Frequency of Acute Pain Episodes in Sickle Cell Disease Patients from Odisha State, India

Autor:	Satyabrata Meher, Kishalaya Das, Bimal Prasad Jit, Prasanta Purohit, Jyoti Ranjan Mohanty, Siris Patel, Avinash Pradhan, Rajendra Kumar Behera, Shalini Sinha, Pradeep Kumar Mohanty, Padmalaya Das
Rok vydání:	2019
Předmět:	Adult Male medicine.medical_specialty Erythrocytes Epinephrine Clinical Biochemistry Cell India Adhesion (medicine) Anemia Sickle Cell Disease 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine Cyclic AMP medicine Humans Fetal Hemoglobin Genetics (clinical) Acute pain business.industry Biochemistry (medical) Hematology medicine.disease Acute Pain medicine.anatomical_structure Endocrinology Case-Control Studies 030220 oncology & carcinogenesis Female business 030215 immunology medicine.drug
Zdroj:	Hemoglobin. 43:88-94
ISSN:	1532-432X 0363-0269
Popis:	Vaso-occlusive crisis (VOC) occurs more frequently during stress in sickle cell disease patients. Epinephrine released during stress increases adhesion of sickled red blood cells (RBCs) to endothelium and to leukocytes, a process mediated through erythrocyte cyclic adenosine monophosphate (cAMP). Increased adhesion of sickled RBCs retards blood flow through the capillaries and promotes vaso-occlusion. Therefore, we examined the association of RBC-cAMP levels with frequency of acute pain episodes in sickle cell disease subjects. Using a case control study design, we measured RBC-cAMP levels, fetal hemoglobin (Hb F), α-thalassemia (α-thal) and other hematological parameters at baseline (sham treated) and after stimulation with epinephrine. The cases consisted of sickle cell disease subjects with three or more acute pain episodes in the last 12 months, and those without a single acute pain episode in the last 12 months were considered as controls. Significantly higher cAMP values were found in cases than the controls, in both sham treated (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257e59532a8c6699d6ae1684bd9ba550 https://doi.org/10.1080/03630269.2019.1623248 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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