Interleukin-1β Stimulates Corticotropin-Releasing Hormone (CRH) and Adrenocorticotropin (ACTH) Release by Rat Adrenal Gland in Vitro
| Autor: | Paola G. Andreis, Ludwik K. Malendowicz, Giuseppina Mazzocchi, Gastone G. Nussdorfer, Musajo Fg |
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| Rok vydání: | 1993 |
| Předmět: |
endocrine system
medicine.medical_specialty Rat Adrenal Gland Interleukin Cell Biology Biology In vitro Rat Adrenals Interleukin 1β Cellular and Molecular Neuroscience Corticotropin-releasing hormone Endocrinology Internal medicine medicine Secretagogue Molecular Biology hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Molecular and Cellular Neuroscience. 4:267-270 |
| ISSN: | 1044-7431 |
| DOI: | 10.1006/mcne.1993.1034 |
| Popis: | CRH and ACTH immunoreactivities (ir) were present in rat adrenal glands but not in adrenocortical autotransplants lacking chromaffin cells. Interleukin-1β (IL-1β) dose-dependently elicited CRH-ir and ACTH-ir release by decorticated adrenal fragments mainly composed of zona-medullaris tissue; the minimum effective concentration was 10 -10 /10 -8 M , and the maximal one was 10 -6 M . The IL-1β (10 -6 M )-induced ACTH release by our preparations was completely blocked by α-helical-CRH (10 -6 M ), a competitive inhibitor of CRH. These findings suggest that chromaffin medullary cells of the rat adrenals contain a CRH/ACTH system, duplicating that operating at the hypothalamohypophyseal level, which is stimulated by IL-1β. Thus, the mechanism underlying the well-known glucocorticoid secretagogue effect of interleukins may involve the activation of both the central and the peripheral branch of the hypothalamohypophyseal-adrenal axis. |
| Databáze: | OpenAIRE |
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