Neurologic manifestations of antiphospholipid syndrome
| Autor: | Fabiano Ferreira Abrantes, G S Silva, A. W. S. de Souza, Irapuá Ferreira Ricarte, Fabio Fieni Toso, Orlando Graziani Povoas Barsottini, L A Dutra, Danieli Andrade |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
030203 arthritis & rheumatology
Brain Diseases Pediatrics medicine.medical_specialty Movement disorders business.industry Central nervous system Anticoagulants Antiphospholipid Syndrome medicine.disease Thrombosis Transverse myelitis Microcirculation Pathogenesis 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Rheumatology Antiphospholipid syndrome medicine Humans medicine.symptom business Stroke 030217 neurology & neurosurgery |
| Zdroj: | Lupus. 27:1404-1414 |
| ISSN: | 1477-0962 0961-2033 |
| DOI: | 10.1177/0961203318776110 |
| Popis: | Neurological involvement in antiphospholipid antibody syndrome (APS) is common, and its occurrence increases morbidity and mortality. Patients may present variable neurological involvement, such as cerebrovascular disease, cognitive dysfunction, headache, seizures, movement disorders, multiple sclerosis-like syndrome, transverse myelitis and ocular symptoms. Most neurological manifestations are associated with thrombosis of the microcirculation or of large vessels; nonetheless, there is compelling evidence suggesting that, in some cases, symptoms are secondary to an immune-mediated pathogenesis, with direct binding of aPL on neurons and glia. Herein we describe clinical characteristics and management of neurological APS manifestations. |
| Databáze: | OpenAIRE |
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