Correlation between brain damage, associated biomarkers, and medication in psychiatric inpatients: A cross-sectional study
| Autor: | Yukihiro Ishii, Tetsuya Hisaoka, Shun Kusanishi, Tetsuto Kanzaki, Yoriyasu Uju, Asuka Yasukawa, Kazuei Igarashi, Tatsuro Hayakawa, Kanako Murakami, Masafumi Miura, Seiko Okamoto, Kazumi Tsukada, Chieko Nakano, Keisuke Sekine, Mutsumi Mizoi, Yasuhiko Mizuta, Seisuke Mimori, Mamoru Sato, Taro Yoshimi, Reiko Yasui, Mizuho Nakamura, Shunichi Mishima, Takeshi Uemura, Keiko Kashiwagi, Madoka Yoshida |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Brain Infarction Male medicine.medical_specialty Cross-sectional study Clinical Biochemistry Brain damage 030204 cardiovascular system & hematology behavioral disciplines and activities Biochemistry 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Psychiatry Stroke Inpatients Mood Disorders business.industry Incidence (epidemiology) Biochemistry (medical) General Medicine Middle Aged medicine.disease Cross-Sectional Studies Mood Mood disorders Schizophrenia Brain Injuries Relative risk Female medicine.symptom business Biomarkers 030217 neurology & neurosurgery Antipsychotic Agents |
| Zdroj: | Clinica Chimica Acta. 464:50-56 |
| ISSN: | 0009-8981 |
| Popis: | Background We clarified the correlation between brain damage, associated biomarkers and medication in psychiatric patients, because patients with schizophrenia have an increased risk of stroke. Methods The cross-sectional study was performed from January 2013 to December 2015. Study participants were 96 hospitalized patients (41 men and 55 women) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa, Chiba, Japan. Patients were classified into schizophrenia (n = 70) and mood disorders (n = 26) by psychiatric diagnoses with DSM-IV-TR criteria. Results The incidence of brain damage [symptomatic and silent brain infarctions (SBIs) and white matter hyperintensity (WMH)] was correlated more with mood disorders than with schizophrenia. It has been previously shown that the concentrations of protein-conjugated acrolein (PC-Acro) and interleukin-6 (IL-6) increased in plasma of brain infarction patients together with C-reactive protein (CRP). The concentration of PC-Acro was significantly higher in patients with mood disorders than in those with schizophrenia. The concentration of IL-6 in both groups was nearly equal to that in the control group, but that of CRP in both groups, especially in mood disorders, was higher than that in the control group. Accordingly, the relative risk value for brain infarction was higher in patients with mood disorders than with schizophrenia. Medication with atypical antipsychotics reduced PC-Acro significantly in all psychiatric patients and reduced IL-6 in mood disorder patients. Conclusion Measurement of 3 biomarkers (CRP, PC-Acro and IL-6) are probably useful for judgement of severity of brain damage and effectiveness of medication in psychiatric patients. |
| Databáze: | OpenAIRE |
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