Metabolic dysfunction is associated with steatosis but no other histologic features in nonalcoholic fatty liver disease

Autor: Yi-Ning, Dai, Cheng-Fu, Xu, Hong-Ying, Pan, Hai-Jun, Huang, Mei-Juan, Chen, You-Ming, Li, Chao-Hui, Yu
Rok vydání: 2022
Předmět:
Zdroj: World Journal of Clinical Cases. 10:4097-4109
ISSN: 2307-8960
DOI: 10.12998/wjcc.v10.i13.4097
Popis: Recently, nonalcoholic fatty liver disease (NAFLD) has been renamed metabolic-associated fatty liver disease (MAFLD). Based on the definition for MAFLD, a group of non-obese and metabolically healthy individuals with fatty liver are excluded from the newly proposed nomenclature.To analyze the histologic features in the MAFLD and non-MAFLD subgroups of NAFLD.Eighty-three patients with biopsy-proven NAFLD were separated into MAFLD and non-MAFLD groups. The diagnosis of MAFLD was established as hepatic steatosis along with obesity/diabetes or evidence of metabolic dysfunction. The histologic features were compared according to different metabolic disorders and liver enzyme levels.MAFLD individuals had a higher NAFLD activity score (Metabolic dysfunction is associated with hepatic steatosis but no other histologic features in NAFLD. Further research is needed to assess the dynamic histologic characteristics in NAFLD based on the presence or absence of metabolic disorders.
Databáze: OpenAIRE