Circadian Regulation of Adult Stem Cell Homeostasis and Aging
| Autor: | Patrick Simon Welz, Salvador Aznar Benitah |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cell physiology
Aging Circadian clock Stem cells Biology 03 medical and health sciences 0302 clinical medicine Circadian regulation Envelliment Circadian Clocks Genetics Homeostasis Circadian rhythms Circadian rhythm Ritmes circadiaris 030304 developmental biology 0303 health sciences Cell Biology Circadian Rhythm Adult Stem Cells Molecular Medicine Stem cell Cèl·lules mare Neuroscience 030217 neurology & neurosurgery Function (biology) Adult stem cell |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | The circadian clock temporally organizes cellular physiology throughout the day, allowing daily environmental changes to be anticipated and potentially harmful physiologic processes to be temporally separated. By synchronizing all cells at the tissue level, the circadian clock ensures coherent temporal organismal physiology. Recent advances in our understanding of adult stem cell physiology suggest that aging and perturbations in circadian rhythmicity in stem cells are tightly intertwined. Here we discuss how circadian rhythms regulate and synchronize adult stem cell functions and how alterations in clock function during aging modulate the extrinsic and intrinsic mechanisms that determine adult stem cell homeostasis. |
| Databáze: | OpenAIRE |
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