Perceived medication adherence barriers mediating effects between gastrointestinal symptoms and health-related quality of life in pediatric inflammatory bowel disease
| Autor: | James W, Varni, Robert J, Shulman, Mariella M, Self, Shehzad A, Saeed, George M, Zacur, Ashish S, Patel, Samuel, Nurko, Deborah A, Neigut, James P, Franciosi, Miguel, Saps, Jolanda M, Denham, Chelsea Vaughan, Dark, Cristiane B, Bendo, John F, Pohl |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Constipation Adolescent Gastrointestinal Diseases media_common.quotation_subject Inflammatory bowel disease Severity of Illness Index Medication Adherence 03 medical and health sciences 0302 clinical medicine Quality of life Severity of illness medicine Humans media_common Crohn's disease business.industry Public health Public Health Environmental and Occupational Health medicine.disease Inflammatory Bowel Diseases Ulcerative colitis 030220 oncology & carcinogenesis Physical therapy Quality of Life 030211 gastroenterology & hepatology Female Worry medicine.symptom business |
| Zdroj: | Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 27(1) |
| ISSN: | 1573-2649 |
| Popis: | The primary objective was to investigate the mediating effects of patient-perceived medication adherence barriers in the relationship between gastrointestinal symptoms and generic health-related quality of life (HRQOL) in adolescents with inflammatory bowel disease (IBD). The secondary objective explored patient health communication and gastrointestinal worry as additional mediators with medication adherence barriers in a serial multiple mediator model. The Pediatric Quality of Life Inventory™ Gastrointestinal Symptoms, Medicines, Communication, Gastrointestinal Worry, and Generic Core Scales were completed in a 9-site study by 172 adolescents with IBD. Gastrointestinal Symptoms Scales measuring stomach pain, constipation, or diarrhea and perceived medication adherence barriers were tested for bivariate and multivariate linear associations with HRQOL. Mediational analyses were conducted to test the hypothesized mediating effects of perceived medication adherence barriers as an intervening variable between gastrointestinal symptoms and HRQOL. The predictive effects of gastrointestinal symptoms on HRQOL were mediated in part by perceived medication adherence barriers. Patient health communication was a significant additional mediator. In predictive analytics models utilizing multiple regression analyses, demographic variables, gastrointestinal symptoms (stomach pain, constipation, or diarrhea), and perceived medication adherence barriers significantly accounted for 45, 38, and 29 percent of the variance in HRQOL (all Ps |
| Databáze: | OpenAIRE |
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