Occurrence of two germline-related rheumatoid factor idiotypes in rheumatoid arthritis and in non-rheumatoid seropositive individuals
| Autor: | J. Crowley, John H. Vaughan, Dennis A. Carson, K. Aho, Markku Heliövaara, T. Kouri, T. Palosuo, H. Isomäki, R. Essen |
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| Rok vydání: | 1990 |
| Předmět: |
Idiotype
Immunology Cross Reactions Germline Arthritis Rheumatoid Cohort Studies Germline mutation Immunoglobulin Idiotypes Rheumatoid Factor Humans Immunology and Allergy Medicine Rheumatoid factor Finland Genes Immunoglobulin biology business.industry medicine.disease Cross-Sectional Studies Rheumatoid arthritis biology.protein Population study Immunoglobulin Light Chains Paraproteins Antibody business Research Article Follow-Up Studies |
| Zdroj: | Clinical and Experimental Immunology. 82:250-256 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.1990.tb05435.x |
| Popis: | SUMMARYHuman rheumatoid factor (RF) paraproteins express two distinct light chain cross-reactive idiotypes defined by the monoclonal antibodies 17.109 and 6B6.6. These germline gene-related cross-reactive idiotypes are both carried on Vk3 light chains and are each present on about one-third of IgM RF paraproteins. We assessed the degree to which these idiotypes are represented in polyclonal RFs. We used rheumatoid arthritis (RA) and non-RA RF-positive sera selected from a large cross-sectional population study (the Mini-Finland Health Survey), and sera from a community-based follow-up study of recent-onset RA patients from Heinola, Finland. In the Mini-Finland Health Survey, elevated levels of the 17.109 RF idiotype were seen in sera of 13% of the RA and 19% of the non-RA group; 6B6.6 RF was seen in 26% of the RA and 28% of the non-RA group. In sera of the Heinola follow-up study, 17.109 RF was seen in 12% initially, but in only 3% at 8 years. Similarly, 6B6.6 RF was detected in 25% initially, but in only 7% at 8 years. Ten sera positive for RF prior to the onset of clinical RA were identified from individuals of a second large population study from Finland (North Karelia project); two of these sera exhibited the 6B6.6 idiotype; none exhibited the 17.109 idiotype. The data are consistent with the concept that these germline gene-related cross-reactive RF idiotypes occur frequently in the polyclonal RF of non-RA as well as RA sera, and that in RA the idiotypes may sometimes be reduced or lost as a consequence of somatic diversification of the RF through somatic mutation, usage of new germline genes, or both. |
| Databáze: | OpenAIRE |
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