Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays
| Autor: | Maxim Puchkov, Jörg Huwyler, Daniel Preisig, Felipe Varum, Roberto Bravo, Rainer Alles, Michael Weingartner |
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| Rok vydání: | 2015 |
| Předmět: |
Ions
Chromatography Colon Swine Chemistry Chemistry Pharmaceutical Kinetics Pharmaceutical Science In Vitro Techniques Calcium Carbonate Chitosan chemistry.chemical_compound Drug Delivery Systems Capillary electrophoresis Solubility Drug delivery Mucoadhesion Animals Nanoparticles Particle Tissue Adhesives Dissolution testing Intestinal Mucosa Particle Size Drug carrier |
| Zdroj: | International Journal of Pharmaceutics. 487:157-166 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2015.04.020 |
| Popis: | The objective of the present work was to develop an improved method to quantify particle retention on mucosal tissue under dynamic flow conditions with simultaneous determination of drug dissolution. The principle was to dissolve the collected inert carrier material and quantify specific marker ions by reliable analytical methods. The mucoadhesive model particles consisted of drug-loaded porous calcium carbonate microcarriers coated with chitosan, and quantification of calcium ions by capillary electrophoresis enabled to determine particle-retention kinetics on colonic mucosal tissue. The method was validated by image analysis, and the particle-retention assay was successfully applied to granulate material (125-250 mm) and small particles ( |
| Databáze: | OpenAIRE |
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