Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection
| Autor: | M H Kemmeren, J T Brouwer, R A De Man, Markus Böhm, J M Vrolijk, M Willems, J C den Hollander, K Munte |
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| Přispěvatelé: | Gastroenterology & Hepatology, Dermatology, Pathology, Internal Medicine |
| Rok vydání: | 2003 |
| Předmět: |
Male
Hepatitis C virus Alpha interferon Dermatology Interferon alpha-2 medicine.disease_cause Antiviral Agents Tongue Diseases Melanin chemistry.chemical_compound SDG 3 - Good Health and Well-being Hyperpigmentation medicine Humans Pigmentation disorder Interferon alfa integumentary system business.industry Ribavirin Interferon-alpha Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Recombinant Proteins chemistry Immunology Female Drug Eruptions sense organs medicine.symptom business medicine.drug |
| Zdroj: | British Journal of Dermatology, 149, 390-394. Wiley-Blackwell Publishing Ltd |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1046/j.1365-2133.2003.05422.x |
| Popis: | Many types of skin disorders concomitantly occur with hepatitis C virus infection. These skin lesions may be induced or worsened during antiviral therapy with interferon-alpha (IFN). To our knowledge, hyperpigmentation of the skin--and especially of the tongue--has not been reported so far. We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin. Immunohistochemical analysis of tongue biopsies confirmed the suspicion of melanin deposits in these areas of hyperpigmentation. We hypothesize that during interferon therapy, melanocytes may produce more melanin pigment in the presence of alpha-melanocyte stimulating hormone and sufficient amounts of tyrosine, leading to melanin deposits and clinical hyperpigmentation. |
| Databáze: | OpenAIRE |
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